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HLA-DPB1 Reactive T Cell Receptors for Adoptive Immunotherapy in Allogeneic Stem Cell Transplantation

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Klobuch, Sebastian ; Hammon, Kathrin ; Vatter-Leising, Sarah ; Neidlinger, Elisabeth ; Zwerger, Michael ; Wandel, Annika ; Neuber, Laura Maria ; Heilmeier, Bernhard ; Fichtner, Regina ; Mirbeth, Carina ; Herr, Wolfgang ; Thomas, Simone
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Nov 2020 11:12


HLA-DPB1 antigens are mismatched in about 80% of allogeneic hematopoietic stem cell transplantations from HLA 10/10 matched unrelated donors and were shown to be associated with a decreased risk of leukemia relapse. We recently developed a reliable in vitro method to generate HLA-DPB1 mismatch-reactive CD4 T-cell clones from allogeneic donors. Here, we isolated HLA-DPB1 specific T cell receptors ...


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