NCX1 represents an ionic Na+ sensing mechanism in macrophages

URN to cite this document:: urn:nbn:de:bvb:355-epub-441500
DOI to cite this document:: 10.5283/epub.44150

Oliver, Paula M. ; Neubert, Patrick ; Homann, Arne ; Wendelborn, David ; Bär, Anna-Lorena

; Krampert, Luka

; Trum, Maximilian ; Schröder, Agnes ; Ebner, Stefan ; Weichselbaum, Andrea ; Schatz, Valentin ; Linz, Peter ; Veelken, Roland ; Schulte-Schrepping, Jonas

; Aschenbrenner, Anna C. ; Quast, Thomas ; Kurts, Christian ; Geisberger, Sabrina ; Kunzelmann, Karl ; Hammer, Karin ; Binger, Katrina J. ; Titze, Jens ; Müller, Dominik N. ; Kolanus, Waldemar

; Schultze, Joachim L. ; Wagner, Stefan ; Jantsch, Jonathan

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Date of publication of this fulltext: 17 Dec 2020 13:01

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Abstract

Inflammation and infection can trigger local tissue Na(+)accumulation. This Na+-rich environment boosts proinflammatory activation of monocyte/macrophage-like cells (M phi s) and their antimicrobial activity. Enhanced Na+-driven M phi function requires the osmoprotective transcription factor nuclear factor of activated T cells 5 (NFAT5), which augments nitric oxide (NO) production and contributes ...