Polymorphonuclear Cell Chemotaxis and Suicidal NETosis: Simultaneous Observation Using fMLP, PMA, H7, and Live Cell Imaging

URN to cite this document:: urn:nbn:de:bvb:355-epub-441581
DOI to cite this document:: 10.5283/epub.44158

Pai, Delou ; Gruber, Michael

; Pfaehler, Sophie-Marie

; Bredthauer, Andre

; Lehle, Karla ; Trabold, Benedikt

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Date of publication of this fulltext: 12 Nov 2020 13:23

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Abstract

Chemotaxis and the formation of suicidal neutrophil extracellular traps (suicidal NETosis) are key functions of polymorphonuclear cells (PMNs). Neutrophil extracellular traps in particular are known to be significantly involved in the severity of inflammatory and immunological disorders such as rheumatoid arthritis and Crohn's disease. Therefore, detailed knowledge of PMNs is essential for ...