Baier, Julia ; Gänsbauer, Maximilian ; Giessler, Claudia ; Arnold, Harald ; Muske, Mercedes ; Schleicher, Ulrike ; Lukassen, Sören 
; Ekici, Arif ; Rauh, Manfred ; Daniel, Christoph ; Hartmann, Arndt ; Schmid, Benjamin ; Tripal, Philipp ; Dettmer, Katja ; Oefner, Peter J. ; Atreya, Raja ; Wirtz, Stefan ; Bogdan, Christian ; Mattner, Jochen
; Ekici, Arif ; Rauh, Manfred ; Daniel, Christoph ; Hartmann, Arndt ; Schmid, Benjamin ; Tripal, Philipp ; Dettmer, Katja ; Oefner, Peter J. ; Atreya, Raja ; Wirtz, Stefan ; Bogdan, Christian ; Mattner, Jochen 
Abstract
Arginase 1 (Arg1), which converts L-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects. However, the function of Arg1 in inflammatory bowel disease (IBD) remains poorly characterized. Here, we found that Arg1 expression correlated with the degree of inflammation in intestinal tissues from IBD patients. In mice, Arg1 was upregulated in an IL-4/IL-13(-) and intestinal ...
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