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Arginase impedes the resolution of colitis by altering the microbiome and metabolome

Baier, Julia ; Gänsbauer, Maximilian ; Giessler, Claudia ; Arnold, Harald ; Muske, Mercedes ; Schleicher, Ulrike ; Lukassen, Sören ; Ekici, Arif ; Rauh, Manfred ; Daniel, Christoph ; Hartmann, Arndt ; Schmid, Benjamin ; Tripal, Philipp ; Dettmer, Katja ; Oefner, Peter J. ; Atreya, Raja ; Wirtz, Stefan ; Bogdan, Christian ; Mattner, Jochen



Abstract

Arginase 1 (Arg1), which converts L-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects. However, the function of Arg1 in inflammatory bowel disease (IBD) remains poorly characterized. Here, we found that Arg1 expression correlated with the degree of inflammation in intestinal tissues from IBD patients. In mice, Arg1 was upregulated in an IL-4/IL-13(-) and intestinal ...

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