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Quantification of microdialysis related variability in humans: Clinical trial design recommendations

Busse, David ; Simon, Philipp ; Michelet, Robin ; Ehmann, Lisa ; Mehner, Frank ; Dorn, Christoph ; Kratzer, Alexander ; Huisinga, Wilhelm ; Wrigge, Hermann ; Petroff, David ; Kloft, Charlotte


Objective: Target-site concentrations obtained via the catheter-based minimally invasive microdialysis technique often exhibit high variability. Catheter calibration is commonly performed via retrodialysis, in which a transformation factor, termed relative recovery (RR), is determined. Leveraging RR values from a rich data set of a very large clinical microdialysis study, promised to contribute ...


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