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Empagliflozin inhibits Na + /H + exchanger activity in human atrial cardiomyocytes

URN to cite this document:
urn:nbn:de:bvb:355-epub-442745
DOI to cite this document:
10.5283/epub.44274
Trum, Maximilian ; Riechel, Johannes ; Lebek, Simon ; Pabel, Steffen ; Sossalla, Samuel T. ; Hirt, Stephan ; Arzt, Michael ; Maier, Lars S. ; Wagner, Stefan
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Date of publication of this fulltext: 14 Jan 2021 16:15


Abstract

Aims Recent clinical trials have proven gliflozins to be cardioprotective in diabetic and non‐diabetic patients. However, the underlying mechanisms are incompletely understood. A potential inhibition of cardiac Na+/H+ exchanger 1 (NHE1) has been suggested in animal models. We investigated the effect of empagliflozin on NHE1 activity in human atrial cardiomyocytes. Methods and ...

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