Empagliflozin inhibits Na + /H + exchanger activity in human atrial cardiomyocytes

URN to cite this document:: urn:nbn:de:bvb:355-epub-442745
DOI to cite this document:: 10.5283/epub.44274

Trum, Maximilian

; Riechel, Johannes ; Lebek, Simon ; Pabel, Steffen ; Sossalla, Samuel T. ; Hirt, Stephan ; Arzt, Michael ; Maier, Lars S. ; Wagner, Stefan

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Date of publication of this fulltext: 14 Jan 2021 16:15

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Abstract

Aims Recent clinical trials have proven gliflozins to be cardioprotective in diabetic and non-diabetic patients. However, the underlying mechanisms are incompletely understood. A potential inhibition of cardiac Na+/H(+)exchanger 1 (NHE1) has been suggested in animal models. We investigated the effect of empagliflozin on NHE1 activity in human atrial cardiomyocytes. Methods and results Expression ...