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Empagliflozin inhibits Na + /H + exchanger activity in human atrial cardiomyocytes

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Trum, Maximilian ; Riechel, Johannes ; Lebek, Simon ; Pabel, Steffen ; Sossalla, Samuel T. ; Hirt, Stephan ; Arzt, Michael ; Maier, Lars S. ; Wagner, Stefan
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 14 Jan 2021 16:15


Aims Recent clinical trials have proven gliflozins to be cardioprotective in diabetic and non-diabetic patients. However, the underlying mechanisms are incompletely understood. A potential inhibition of cardiac Na+/H(+)exchanger 1 (NHE1) has been suggested in animal models. We investigated the effect of empagliflozin on NHE1 activity in human atrial cardiomyocytes. Methods and results Expression ...


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