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Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery

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Peterhoff, David ; Thalhauser, Stefanie ; Sobczak, Jan M. ; Mohsen, Mona O. ; Voigt, Christoph ; Seifert, Nicole ; Neckermann, Patrick ; Hauser, Alexandra ; Ding, Song ; Sattentau, Quentin ; Bachmann, Martin F. ; Breunig, Miriam ; Wagner, Ralf
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Jan 2022 16:48


The delivery of HIV-1 envelope (Env) trimer-based immunogens on the surface of nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent, durable and broad neutralizing antibody (bnAb) response. Towards that goal, we examined the covalent conjugation of Env to 100 nm and 200 nm silica nanoparticles (SiNPs) to optimize conjugation density and attachment stability. Env ...


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