Augmenting the Immune Response against a Stabilized HIV-1 Clade C Envelope Trimer by Silica Nanoparticle Delivery

URN to cite this document:: urn:nbn:de:bvb:355-epub-443285
DOI to cite this document:: 10.5283/epub.44328

Peterhoff, David

; Thalhauser, Stefanie ; Sobczak, Jan M. ; Mohsen, Mona O. ; Voigt, Christoph ; Seifert, Nicole

; Neckermann, Patrick ; Hauser, Alexandra

; Ding, Song ; Sattentau, Quentin ; Bachmann, Martin F.

; Breunig, Miriam

; Wagner, Ralf

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Date of publication of this fulltext: 12 Jan 2022 16:48

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Abstract

The delivery of HIV-1 envelope (Env) trimer-based immunogens on the surface of nanoparticles holds promise to promote immunogenicity with the aim of inducing a potent, durable and broad neutralizing antibody (bnAb) response. Towards that goal, we examined the covalent conjugation of Env to 100 nm and 200 nm silica nanoparticles (SiNPs) to optimize conjugation density and attachment stability. Env ...