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Single-molecule analysis of transcription initiation in archaea and eukaryotes

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Kramm, Kevin Oliver
Date of publication of this fulltext: 21 Dec 2020 11:03

Abstract (English)

Transcription is the transfer of information stored in the DNA genome into RNA and an essential process for cellular life. In all three domains of life, transcription is carried out by structurally conserved RNA polymerases (RNAP). archaea employ only a single RNAP while eukaryotes have evolved three functionally distinct variants, RNAP I, II and III. Transcription is a cyclic process divided ...


Translation of the abstract (German)

Transkription ist der Transfer von im DNA-Genom gespeicherten Informationen in RNA und daher ein wichtiger Prozess für zelluläres Leben. Transkription erfolgt in allen drei Domänen des Lebens durch strukturell konservierte RNA-Polymerasen (RNAPs). Archaeen verwenden nur eine einzige RNAP, während Eukaryoten drei funktionell unterschiedliche Varianten entwickelt haben, RNAP I, II und III. ...


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