Fasudil Loaded PLGA Microspheres as Potential Intravitreal Depot Formulation for Glaucoma Therapy

URN to cite this document:: urn:nbn:de:bvb:355-epub-444280
DOI to cite this document:: 10.5283/epub.44428

Mietzner, Raphael

; Kade, Christian ; Froemel, Franziska ; Pauly, Diana ; Stamer, W. Daniel ; Ohlmann, Andreas ; Wegener, Joachim ; Fuchshofer, Rudolf ; Breunig, Miriam

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Date of publication of this fulltext: 15 Jan 2021 10:41

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Abstract

Rho-associated protein kinase (ROCK) inhibitors allow for causative glaucoma therapy. Unfortunately, topically applied ROCK inhibitors suffer from high incidence of hyperemia and low intraocular bioavailability. Therefore, we propose the use of poly (lactide-co-glycolide) (PLGA) microspheres as a depot formulation for intravitreal injection to supply outflow tissues with the ROCK inhibitor ...