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Steric Shielding of cRGD-Functionalized Nanoparticles from Premature Exposition to Off-Target Endothelial Cells under a Physiological Flow

Fleischmann, Daniel ; Maslanka-Figueroa, Sara ; Göpferich, Achim



Abstract

One of the central impediments for the clinical translation of targeted nanomaterials is their extensive off-target deposition, which can be mainly attributed to the addressed cellular surface structures being ubiquitously present in various other regions, such as the vascular system. This is especially important for the integrin receptor family, which is frequently addressed with ligands such as ...

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