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Cross‐presentation of dead‐cell‐associated antigens by DNGR‐1⁺ dendritic cells contributes to chronic allograft rejection in mice

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Brunner, Stefan M. ; Balam, Saidou ; Kesselring, Rebecca ; Eggenhofer, Elke ; Blaimer, Stephanie ; Evert, Katja ; Evert, Matthias ; Schlitt, Hans J. ; Geissler, Edward K. ; van Blijswijk, Janneke ; Lee, Sonia ; Reis e Sousa, Caetano ; Fichtner-Feigl, Stefan
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Jan 2021 18:02


The purpose of this study was to elucidate whether DC NK lectin group receptor‐1 (DNGR‐1)‐dependent cross‐presentation of dead‐cell‐associated antigens occurs after transplantation and contributes to CD8+ T cell responses, chronic allograft rejection (CAR), and fibrosis. BALB/c or C57BL/6 hearts were heterotopically transplanted into WT, Clec9a−/−, or Batf3−/− recipient C57BL/6 mice. Allografts ...


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