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The immunological Warburg effect: Can a metabolic‐tumor‐stroma score (MeTS) guide cancer immunotherapy?

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Siska, Peter J. ; Singer, Katrin ; Evert, Katja ; Renner, Kathrin ; Kreutz, Marina
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Jan 2021 18:35


The “glycolytic switch” also known as the “Warburg effect” is a key feature of tumor cells and leads to the accumulation of lactate and protons in the tumor environment. Intriguingly, non‐malignant lymphocytes or stromal cells such as tumor‐associated macrophages and cancer‐associated fibroblasts contribute to the lactate accumulation in the tumor environment, a phenomenon described as the ...


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