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The immunological Warburg effect: Can a metabolic‐tumor‐stroma score (MeTS) guide cancer immunotherapy?

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Siska, Peter J. ; Singer, Katrin ; Evert, Katja ; Renner, Kathrin ; Kreutz, Marina
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Jan 2021 18:35

This publication is part of the DEAL contract with Wiley.


The "glycolytic switch" also known as the "Warburg effect" is a key feature of tumor cells and leads to the accumulation of lactate and protons in the tumor environment. Intriguingly, non-malignant lymphocytes or stromal cells such as tumor-associated macrophages and cancer-associated fibroblasts contribute to the lactate accumulation in the tumor environment, a phenomenon described as the ...


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