Heat-Inactivation of Human Serum Destroys C1 Inhibitor, Pro-motes Immune Complex Formation, and Improves Human T Cell Function

URN to cite this document:: urn:nbn:de:bvb:355-epub-447230
DOI to cite this document:: 10.5283/epub.44723

Renner-Sattler, Kathrin ; Fante, Matthias A. ; Decking, Sonja-Maria ; Bruss, Christina

; Schreml, Stephan

; Siska, Peter J.

; Kreutz, Marina

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Date of publication of this fulltext: 09 Mar 2021 14:42

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Abstract

Heat-inactivation of sera is used to reduce possible disturbing effects of complement factors in cell-culture experiments, but it is controversially discussed whether this procedure is appropriate or could be neglected. Here, we report a strong impact of heat-inactivation of human sera on the activation and effector functions of human CD4+ T cells. While T cells cultured with native sera were ...