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Alterations of the renin angiotensin system in human end-stage heart failure before and after mechanical cardiac unloading by LVAD support

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Birner, Christoph ; Messmann, Rebecca ; Dietl, Alexander ; Wagner, Stefan ; Domenig, Oliver ; Jungbauer, Carsten ; Luchner, Andreas ; Maier, Lars S. ; Schopka, Simon ; Hirt, Stephan ; Schmid, Christof
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Feb 2021 09:09

This publication is part of the DEAL contract with Springer.


Heart transplantation is often an unrealizable therapeutic option for end-stage heart failure, which is why mechanical left ventricular assist devices (LVADs) become an increasingly important therapeutic alternative. Currently, there is a lack of information about molecular mechanisms which are influenced by LVADs, particularly regarding the pathophysiologically critical renin angiotensin system ...


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