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Targeted Delivery of Soluble Guanylate Cyclase (sGC) Activator Cinaciguat to Renal Mesangial Cells via Virus-Mimetic Nanoparticles Potentiates Anti-Fibrotic Effects by cGMP-Mediated Suppression of the TGF-β Pathway

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Göpferich, Achim ; Fleischmann, Daniel ; Harloff, Manuela ; Figueroa, Sara Maslanka ; Schlossmann, Jens
License: Creative Commons Attribution No Derivatives 4.0
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Date of publication of this fulltext: 11 Mar 2021 08:37


Diabetic nephropathy (DN) ranks among the most detrimental long-term effects of diabetes, affecting more than 30% of all patients. Within the diseased kidney, intraglomerular mesangial cells play a key role in facilitating the pro-fibrotic turnover of extracellular matrix components and a progredient glomerular hyperproliferation. These pathological effects are in part caused by an impaired ...


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