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Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice

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Pabel, Steffen ; Ahmad, Shakil ; Tirilomis, Petros ; Stehle, Thea ; Mustroph, Julian ; Holzamer, Andreas ; Hilker, Michael ; Maier, Lars S. ; Sossalla, Samuel ; ; ; ; ;
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 08 Feb 2021 11:41

This publication is part of the DEAL contract with Springer.


Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side effects and low efficacy. Thus, the identification of new antiarrhythmic targets is of clinical interest. Recent genome studies suggested an involvement of SCN10A sodium channels (Na(V)1.8) in atrial electrophysiology. This study investigated the role and involvement of Na(V)1.8 (SCN10A) in arrhythmia ...


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