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Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

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Winkler, Thomas W. ; Grassmann, Felix ; Brandl, Caroline ; Kiel, Christina ; Günther, Felix ; Strunz, Tobias ; Weidner, Lorraine ; Zimmermann, Martina E. ; Korb, Christina A. ; Poplawski, Alicia ; Schuster, Alexander K. ; Müller-Nurasyid, Martina ; Peters, Annette ; Rauscher, Franziska G. ; Elze, Tobias ; Horn, Katrin ; Scholz, Markus ; Cañadas-Garre, Marisa ; McKnight, Amy Jayne ; Quinn, Nicola ; Hogg, Ruth E. ; Küchenhoff, Helmut ; Heid, Iris M. ; Stark, Klaus J. ; Weber, Bernhard H. F.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Feb 2021 09:14


Background Advanced age-related macular degeneration (AMD) is a leading cause of blindness. While around half of the genetic contribution to advanced AMD has been uncovered, little is known about the genetic architecture of early AMD. Methods To identify genetic factors for early AMD, we conducted a genome-wide association study (GWAS) meta-analysis (14,034 cases, 91,214 controls, 11 sources of ...


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