In this paper we investigate the relationship of Information Science (IS) and the Digital Humanities (DH) by means of a scientometric comparison of academic journals from the respective disciplines. In order to identify scholarly practices for both disciplines, we apply a recent variant of LDA topic modeling that makes use of additional hierarchical clustering. The results reveal the existence of characteristic topic areas for both IS (information retrieval, information seeking behavior, scientometrics) and DH (computational linguistics, distant reading and digital editions) that can be used to distinguish them as disciplines in their own right. However, there is also a larger shared area of practices related to information management and also a few shared topic clusters that indicate a common ground for – mostly methodological – exchange between the two disciplines.