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hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways

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Li, Shushan ; Stöckl, Sabine ; Lukas, Christoph ; Götz, Julia ; Herrmann, Marietta ; Federlin, Marianne ; Grässel, Susanne
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Feb 2021 18:18


Background: Human bone marrow-derived mesenchymal stromal cells (hBMSCs) provide a promising therapeutic approach in the cell-based therapy of osteoarthritis (OA). However, several disadvantages evolved recently, including immune responses of the host and regulatory hurdles, making it necessary to search for alternative treatment options. Extracellular vesicles (EVs) are released by multiple cell ...


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