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Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation

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Heck, A. L. ; Mishra, S. ; Prenzel, T. ; Feulner, L. ; Achhammer, E. ; Särchen, V. ; Blagg, B. S. J. ; Schneider-Brachert, W. ; Schütze, S. ; Fritsch, Jürgen
License: Creative Commons Attribution No Derivatives 4.0
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Date of publication of this fulltext: 19 Mar 2021 13:21


Signaling via TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Previous reports demonstrated that pro-survival signaling emanates from membrane resident TNF-R1 complexes (complex I) while only internalized TNF-R1 complexes are capable for DISC formation (complex II) and thus, apoptosis induction. Internalized TNF-R1 containing endosomes ...


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