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A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications

Ziegler, Christian ; Graf, Moritz ; Beck, Sebastian ; Göpferich, Achim



Abstract

Hydrogels are very attractive materials to embed biologics for controlled release over long timescales. However, aqueous preparations pose certain obstacles regarding protein integrity, stability of functional groups, and loading capacity. To overcome these obstacles, the Diels-Alder reaction of furyl- and maleimide-functionalized eight-armed poly(ethylene glycol) (PEG) was used for the polymer ...

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