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Rab27a GTPase modulates L-type Ca 2+ channel function via interaction with the II–III linker of Ca V 1.3 subunit

Reichhart, Nadine ; Markowski, Magdalena ; Ishiyama, Shimpei ; Wagner, Andrea ; Crespo-Garcia, Sergio ; Schorb, Talitha ; Ramalho, José S. ; Milenkovic, Vladimir M. ; Föckler, Renate ; Seabra, Miguel C. ; Strauß, Olaf



Abstract

In a variety of cells, secretory processes require the activation of both Rab27a and L-type channels of the CaV1.3 subtype. In the retinal pigment epithelium (RPE), Rab27a and CaV1.3 channels regulate growth-factor secretion towards its basolateral side. Analysis of murine retina sections revealed a co-localization of both Rab27a and CaV1.3 at the basolateral membrane of the RPE. Heterologously ...

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