Validation of an apoptosis assay for extracorporeal photopheresis

URN to cite this document:: urn:nbn:de:bvb:355-epub-451833
DOI to cite this document:: 10.5283/epub.45183

Hähnel, Viola ; Dormann, Frauke ; Kronenberg, Katharina ; Hutchinson, James A. ; Burkhardt, Ralph

; Ahrens, Norbert

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Date of publication of this fulltext: 11 Mar 2021 10:33

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Abstract

Objectives This validation study investigated a flow cytometric apoptosis assay according to good manufacturing practice (GMP). Background Extracorporeal photopheresis (ECP) is a treatment for various immunological diseases and cutaneous T-cell lymphomas. It is based on the induction of apoptosis by 8-methoxypsoralene and ultraviolet A light. The quantification of apoptosis is therefore essential ...