Mesangial Cells Regulate the Single Nephron GFR and Preserve the Integrity of the Glomerular Filtration Barrier: An Intravital Multiphoton Microscopy Study

URN to cite this document:: urn:nbn:de:bvb:355-epub-451910
DOI to cite this document:: 10.5283/epub.45191

Ziegler, Vera ; Fremter, Katharina ; Helmchen, Julia ; Witzgall, Ralph ; Castrop, Hayo

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Date of publication of this fulltext: 11 Mar 2021 11:48

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Abstract

Aim The intraglomerular mesangial cells are located between the glomerular capillaries. Here we hypothesized that mesangial cells regulate the single nephron glomerular filtration rate (snGFR) and that mesangial cells support the integrity of the glomerular filtration barrier. Methods We assessed the function of mesangial cells in vivo by multiphoton microscopy. Mesangial cells were depleted in ...