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Mesangial Cells Regulate the Single Nephron GFR and Preserve the Integrity of the Glomerular Filtration Barrier: An Intravital Multiphoton Microscopy Study

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Ziegler, Vera ; Fremter, Katharina ; Helmchen, Julia ; Witzgall, Ralph ; Castrop, Hayo
Date of publication of this fulltext: 11 Mar 2021 11:48

This publication is part of the DEAL contract with Wiley.


Aim The intraglomerular mesangial cells are located between the glomerular capillaries. Here we hypothesized that mesangial cells regulate the single nephron glomerular filtration rate (snGFR) and that mesangial cells support the integrity of the glomerular filtration barrier. Methods We assessed the function of mesangial cells in vivo by multiphoton microscopy. Mesangial cells were depleted in ...


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