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Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite

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Oefner, Peter J. ; Dettmer, Katja ; Berger, Raffaela Sarah ; Wachsmuth, Christian J. ; Waldhier, Magdalena C. ; Renner-Sattler, Kathrin ; Thomas, Simone ; Chaturvedi, Anuhar ; Niller, Hans Helmut ; Bumes, Elisabeth ; Hau, Peter ; Proescholdt, Martin A. ; Gronwald, Wolfram ; Heuser, Michael ; Kreutz, Marina
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Apr 2021 14:39


In recent years, onco-metabolites like D-2-hydroxyglutarate, which is produced in isocitrate dehydrogenase-mutated tumors, have gained increasing interest. Here, we report a metabolite in human specimens that is closely related to 2-hydroxyglutarate: the intramolecular ester of 2-hydroxyglutarate, 2-hydroxyglutarate-γ-lactone. Using 13C5-L-glutamine tracer analysis, we showed that ...


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