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Lactonization of the Oncometabolite D-2-Hydroxyglutarate Produces a Novel Endogenous Metabolite

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Oefner, Peter J. ; Dettmer, Katja ; Berger, Raffaela Sarah ; Wachsmuth, Christian J. ; Waldhier, Magdalena C. ; Renner-Sattler, Kathrin ; Thomas, Simone ; Chaturvedi, Anuhar ; Niller, Hans Helmut ; Bumes, Elisabeth ; Hau, Peter ; Proescholdt, Martin A. ; Gronwald, Wolfram ; Heuser, Michael ; Kreutz, Marina
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Apr 2021 14:39


Simple Summary Somatic mutations in isocitrate dehydrogenase give rise to the excessive production and accumulation of D-2-hydroxyglutarate in certain malignancies. In addition to this well-described oncometabolite, we discovered a chemically related metabolite, namely 2-hydroxyglutarate-gamma-lactone, which is derived directly from 2-hydroxyglutarate. This novel metabolite may impact the ...


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