| License: Creative Commons Attribution 4.0 PDF - Published Version (3MB) |
- URN to cite this document:
- urn:nbn:de:bvb:355-epub-451946
- DOI to cite this document:
- 10.5283/epub.45194
Abstract
Simple Summary Somatic mutations in isocitrate dehydrogenase give rise to the excessive production and accumulation of D-2-hydroxyglutarate in certain malignancies. In addition to this well-described oncometabolite, we discovered a chemically related metabolite, namely 2-hydroxyglutarate-gamma-lactone, which is derived directly from 2-hydroxyglutarate. This novel metabolite may impact the ...

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