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- URN to cite this document:
- urn:nbn:de:bvb:355-epub-451946
- DOI to cite this document:
- 10.5283/epub.45194
Oefner, Peter J. 
; Dettmer, Katja ; Berger, Raffaela Sarah ; Wachsmuth, Christian J. ; Waldhier, Magdalena C. ; Renner-Sattler, Kathrin ; Thomas, Simone ; Chaturvedi, Anuhar ; Niller, Hans Helmut ; Bumes, Elisabeth ; Hau, Peter ; Proescholdt, Martin A. ; Gronwald, Wolfram ; Heuser, Michael ; Kreutz, Marina
; Dettmer, Katja ; Berger, Raffaela Sarah ; Wachsmuth, Christian J. ; Waldhier, Magdalena C. ; Renner-Sattler, Kathrin ; Thomas, Simone ; Chaturvedi, Anuhar ; Niller, Hans Helmut ; Bumes, Elisabeth ; Hau, Peter ; Proescholdt, Martin A. ; Gronwald, Wolfram ; Heuser, Michael ; Kreutz, Marina 
Abstract
Simple Summary Somatic mutations in isocitrate dehydrogenase give rise to the excessive production and accumulation of D-2-hydroxyglutarate in certain malignancies. In addition to this well-described oncometabolite, we discovered a chemically related metabolite, namely 2-hydroxyglutarate-gamma-lactone, which is derived directly from 2-hydroxyglutarate. This novel metabolite may impact the ...
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