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Use of oral contraceptives in BRCA mutation carriers and risk for ovarian and breast cancer: a systematic review

Huber, D. ; Seitz, S. ; Kast, K. ; Emons, G. ; Ortmann, Olaf


Purpose BRCA mutation carriers have an increased risk of developing breast or ovarian cancer. Oral contraception (OC) is known to increase breast cancer and reduce ovarian cancer risk in the general population. This review analyses the published data on OC and risk of cancer in BRCA mutation carriers. Methods We included all relevant articles published in English from 1995 to 2018. Literature was ...


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