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The first quantitative histomorphological analyses of bone vitality and inflammation in surgical specimens of patients with medication‐related osteonecrosis of the jaw

Mamilos, Andreas ; Spörl, Steffen ; Spanier, Gerrit ; Ettl, Tobias ; Brochhausen, Christoph ; Klingelhöffer, Christoph


Background The purpose of the study was to categorize the vitality and inflammation of resected bone of patients with medication-related osteonecrosis of the jaw (MRONJ) and to correlate the grade of inflammation with the surgical success. Methods This prospective study includes 44 patients with stage III MRONJ. Necrotic bone was resected in a block fashioned way. After demineralization and ...


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