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Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis

URN to cite this document:
urn:nbn:de:bvb:355-epub-452888
DOI to cite this document:
10.5283/epub.45288
Hutchinson, James A. ; Kronenberg, Katharina ; Riquelme, Paloma ; Wenzel, Jürgen J. ; Glehr, Gunther ; Schilling, Hannah-Lou ; Zeman, Florian ; Evert, Katja ; Schmiedel, Martin ; Mickler, Marion ; Drexler, Konstantin ; Bitterer, Florian ; Cordero, Laura ; Beyer, Lukas ; Bach, Christian ; Koestler, Josef ; Burkhardt, Ralph ; Schlitt, Hans J. ; Hellwig, Dirk ; Werner, Jens M. ; Spang, Rainer ; Schmidt, Barbara ; Geissler, Edward K. ; Haferkamp, Sebastian
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Date of publication of this fulltext: 24 Mar 2021 11:20


Abstract

Treatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4+ T cells (TEM cells). Pre-therapy CD4+ TEM cell expansion occurs primarily during autumn or winter in patients ...

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