Go to content
UR Home

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

URN to cite this document:
DOI to cite this document:
Dowling, Jennifer K. ; Afzal, Remsha ; Gearing, Linden J. ; Cervantes-Silva, Mariana P. ; Annett, Stephanie ; Davis, Gavin M. ; De Santi, Chiara ; Assmann, Nadine ; Dettmer, Katja ; Gough, Daniel J. ; Bantug, Glenn R. ; Hamid, Fidinny I. ; Nally, Frances K. ; Duffy, Conor P. ; Gorman, Aoife L. ; Liddicoat, Alex M. ; Lavelle, Ed C. ; Hess, Christoph ; Oefner, Peter J. ; Finlay, David K. ; Davey, Gavin P. ; Robson, Tracy ; Curtis, Annie M. ; Hertzog, Paul J. ; Williams, Bryan R. G. ; McCoy, Claire E.
License: Creative Commons Attribution 4.0
PDF - Published Version
Date of publication of this fulltext: 29 Mar 2021 06:52


Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration. Mechanistically, the catalytic activity and presence of Arg2 at ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons