Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

URN to cite this document:: urn:nbn:de:bvb:355-epub-453906
DOI to cite this document:: 10.5283/epub.45390

Dowling, Jennifer K.

; Afzal, Remsha

; Gearing, Linden J. ; Cervantes-Silva, Mariana P. ; Annett, Stephanie ; Davis, Gavin M. ; De Santi, Chiara ; Assmann, Nadine ; Dettmer, Katja

; Gough, Daniel J.

; Bantug, Glenn R. ; Hamid, Fidinny I. ; Nally, Frances K. ; Duffy, Conor P. ; Gorman, Aoife L. ; Liddicoat, Alex M. ; Lavelle, Ed C. ; Hess, Christoph ; Oefner, Peter J. ; Finlay, David K. ; Davey, Gavin P. ; Robson, Tracy ; Curtis, Annie M. ; Hertzog, Paul J. ; Williams, Bryan R. G. ; McCoy, Claire E.

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Date of publication of this fulltext: 29 Mar 2021 06:52

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Abstract

Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory macrophages, and is critical for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration. Mechanistically, the catalytic activity and presence of Arg2 at ...