Estimates and determinants of SARS-CoV-2 seroprevalence and infection fatality ratio using latent class analysis: the population-based Tirschenreuth study in the hardest-hit German county in spring 2020

URN to cite this document:

urn:nbn:de:bvb:355-epub-455902 Copy

DOI to cite this document:

10.5283/epub.45590 Copy

Wagner, Ralf ; Peterhoff, David ; Beileke, Stephanie ; Günther, Felix ; Berr, Melanie ; Einhauser, Sebastian ; Schütz, Anja ; Niller, Hans-Helmut ; Steininger, Philipp ; Knöll, Antje ; Tenbusch, Matthias ; Maier, Clara ; Kabesch, Michael ; Schedl, Holger ; Küchenhoff, Helmut ; Pfahlberg, Annette B. ; Heid, Iris M. ; Gefeller, Olaf ; Überla, Klaus ; Korn, Klaus ; Stark, Klaus J. ; Gessner, André ; Burkhardt, Ralph

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Date of publication of this fulltext: 25 Jun 2021 16:18

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	2124.61
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	Viruses
Publisher:	MDPI
Place of Publication:	BASEL
Volume:	2021
Number of Issue or Book Chapter:	13
Page Range:	p. 1118
Date:	10 June 2021
Institutions:	Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Projects (Historical):	Open Access Publizieren (DFG)
Identification Number:	Value Type 10.3390/v13061118 DOI
Keywords:	; SARS-CoV-2; seroprevalence; ELISA; CLIA; latent class analysis; antibodies; infection fatality ratio; underreported infections; smoking; senior care homes
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Submitted
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	45590

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Abstract

SARS-CoV-2 infection fatality ratios (IFR) remain controversially discussed with implications for political measures. The German county of Tirschenreuth suffered a severe SARS-CoV-2 outbreak in spring 2020, with particularly high case fatality ratio (CFR). To estimate seroprevalence, underreported infections, and IFR for the Tirschenreuth population aged >= 14 years in June/July 2020, we ...

Abstract

SARS-CoV-2 infection fatality ratios (IFR) remain controversially discussed with implications for political measures. The German county of Tirschenreuth suffered a severe SARS-CoV-2 outbreak in spring 2020, with particularly high case fatality ratio (CFR). To estimate seroprevalence, underreported infections, and IFR for the Tirschenreuth population aged >= 14 years in June/July 2020, we conducted a population-based study including home visits for the elderly, and analyzed 4203 participants for SARS-CoV-2 antibodies via three antibody tests. Latent class analysis yielded 8.6% standardized county-wide seroprevalence, a factor of underreported infections of 5.0, and 2.5% overall IFR. Seroprevalence was two-fold higher among medical workers and one third among current smokers with similar proportions of registered infections. While seroprevalence did not show an age-trend, the factor of underreported infections was 12.2 in the young versus 1.7 for >= 85-year-old. Age-specific IFRs were <0.5% below 60 years of age, 1.0% for age 60-69, and 13.2% for age 70+. Senior care homes accounted for 45% of COVID-19-related deaths, reflected by an IFR of 7.5% among individuals aged 70+ and an overall IFR of 1.4% when excluding senior care home residents from our computation. Our data underscore senior care home infections as key determinant of IFR additionally to age, insufficient targeted testing in the young, and the need for further investigations on behavioral or molecular causes of the fewer infections among current smokers.

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Metadata last modified: 20 Jan 2025 14:46

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