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Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes

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Mack, Matthias ; Renner, Kerstin ; Schwittay, Tobias ; Chaabane, Sophia ; Gottschling, Johanna ; Müller, Christine ; Tiefenböck, Charlotte ; Salewski, Jan-Niklas ; Winter, Frederike ; Buchtler, Simone ; Balam, Saidou ; Malfertheiner, Maximilian Valentin ; Lubnow, Matthias ; Lunz, Dirk ; Graf, Bernhard ; Hitzenbichler, Florian ; Hanses, Frank ; Poeck, Hendrik ; Kreutz, Marina ; Orso, Evelyn ; Burkhardt, Ralph ; Niedermair, Tanja ; Brochhausen, Christoph ; Gessner, Andre ; Salzberger, Bernd
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Feb 2022 17:01


Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, ...


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