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Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals

URN to cite this document:
urn:nbn:de:bvb:355-epub-456783
DOI to cite this document:
10.5283/epub.45678
Kunzelmann, Karl ; Talbi, Khaoula ; Cabrita, Ines ; Schreiber, Rainer
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jun 2021 14:52


Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is caused by loss of function of PKD1 (polycystin 1) or PKD2 (polycystin 2). The Ca2+-activated Cl− channel TMEM16A has a central role in ADPKD. Expression and function of TMEM16A is upregulated in ADPKD which causes enhanced intracellular Ca2+ signaling, cell proliferation, and ion secretion. We analyzed kidneys from Pkd1 knockout mice and ...

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