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Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals

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Kunzelmann, Karl ; Talbi, Khaoula ; Cabrita, Ines ; Schreiber, Rainer
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jun 2021 14:52


Autosomal dominant polycystic kidney disease (ADPKD) is caused by loss of function of PKD1 (polycystin 1) or PKD2 (polycystin 2). The Ca2+-activated Cl- channel TMEM16A has a central role in ADPKD. Expression and function of TMEM16A is upregulated in ADPKD which causes enhanced intracellular Ca2+ signaling, cell proliferation, and ion secretion. We analyzed kidneys from Pkd1 knockout mice and ...


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