| Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (6MB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-456783
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.45678
Zusammenfassung
Autosomal dominant polycystic kidney disease (ADPKD) is caused by loss of function of PKD1 (polycystin 1) or PKD2 (polycystin 2). The Ca2+-activated Cl- channel TMEM16A has a central role in ADPKD. Expression and function of TMEM16A is upregulated in ADPKD which causes enhanced intracellular Ca2+ signaling, cell proliferation, and ion secretion. We analyzed kidneys from Pkd1 knockout mice and ...
Nur für Besitzer und Autoren: Kontrollseite des Eintrags
Downloadstatistik