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Protein binding of clindamycin in vivo by means of intravascular microdialysis in healthy volunteers

Wulkersdorfer, Beatrix ; Wicha, Sebastian G. ; Kurdina, Elizaveta ; Carrion Carrera, Stephan F. ; Matzneller, Peter ; Al Jalali, Valentin ; Vossen, Matthias G. ; Riesenhuber, Sonja ; Lackner, Edith ; Dorn, Christoph ; Zeitlinger, Markus



Abstract

Objectives: The efficacy of an anti-infective drug is influenced by its protein binding (PB), since only the free fraction is active. We hypothesized that PB may vary in vitro and in vivo, and used clindamycin, a drug with high and concentration-dependent PB to investigate this hypothesis. Methods: Six healthy volunteers received a single intravenous infusion of clindamycin 900 mg. Antibiotic ...

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