A pH‐Triggered Polymer Degradation or Drug Delivery System by Light‐Mediated Cis / Trans Isomerization of o ‐Hydroxy Cinnamates

URN to cite this document:: urn:nbn:de:bvb:355-epub-458710
DOI to cite this document:: 10.5283/epub.45871

Abramov, Alex ; Maiti, Binoy ; Keridou, Ina ; Puiggalí, Jordi ; Reiser, Oliver

; Díaz, David Díaz

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Date of publication of this fulltext: 08 Jun 2021 04:54

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Abstract

A new methodology for the pH-triggered degradation of polymers or for the release of drugs under visible light irradiation based on the cyclization of ortho-hydroxy-cinnamates (oHC) to coumarins is described. The key oHC structural motif can be readily incorporated into the rational design of novel photocleavable polymers via click chemistry. This main-chain moiety undergoes a fast photocleavage ...