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Chronic oxytocin-driven alternative splicing of Crfr2α induces anxiety

URN to cite this document:
urn:nbn:de:bvb:355-epub-458906
DOI to cite this document:
10.5283/epub.45890
Winter, Julia ; Meyer, Magdalena ; Berger, Ilona ; Royer, Melanie ; Bianchi, Marta ; Kuffner, Kerstin ; Peters, Sebastian ; Stang, Simone ; Langgartner, Dominik ; Hartmann, Finn ; Schmidtner, Anna K. ; Reber, Stefan O. ; Bosch, Oliver J. ; Bludau, Anna ; Slattery, David A. ; van den Burg, Erwin H. ; Jurek, Benjamin ; Neumann, Inga D.
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Date of publication of this fulltext: 08 Jun 2021 05:13


Abstract

The neuropeptide oxytocin (OXT) has generated considerable interest as potential treatment for psychiatric disorders, including anxiety and autism spectrum disorders. However, the behavioral and molecular consequences associated with chronic OXT treatment and chronic receptor (OXTR) activation have scarcely been studied, despite the potential therapeutic long-term use of intranasal OXT. Here, we ...

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