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Plasma and soft tissue pharmacokinetics of ceftolozane/tazobactam in healthy volunteers after single and multiple intravenous infusion: a microdialysis study

Al Jalali, V. ; Wölfl-Duchek, M. ; Taubert, M. ; Matzneller, P. ; Lackner, E. ; Dorn, Christoph ; Kratzer, A. ; Wulkersdorfer, B. ; Österreicher, Z ; Zeitlinger, Markus



Abstract

Objectives: To investigate ceftolozane/tazobactam pharmacokinetics (PK) in plasma and interstitial space fluid (ISF) of muscle and subcutaneous tissue and establish a population PK model. Methods: Eight healthy volunteers received four IV doses of 1000/500 mg ceftolozane/tazobactam q8h in a prospective, open-labelled PK study. ISF concentration-time profiles were determined via in vivo ...

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