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G protein-coupled estrogen receptor 1 (GPER-1) and agonist G-1 inhibit growth of ovarian cancer cells by activation of anti-tumoral transcriptome responses: impact of GPER-1 mRNA on survival

Schüler-Toprak, Susanne ; Skrzypczak, Maciej ; Ignatov, Tanja ; Ignatov, Atanas ; Ortmann, Olaf ; Treeck, Oliver


Purpose The present study intended to further elucidate the role of G protein-coupled estrogen receptor 1 (GPER-1) in ovarian cancer by comparing the effects of a GPER-1 knockdown and treatment with its agonist G-1 on cell growth, apoptosis, and the transcriptome of two ovarian cancer cell lines. Furthermore, the role of GPER-1 in ovarian cancer survival was examined. Methods GPER-1 expression in ...


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