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High Na+ Environments Impair Phagocyte Oxidase-Dependent Antibacterial Activity of Neutrophils

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Jantsch, Jonathan ; Krampert, Luka ; Bauer, Katharina ; Ebner, Stefan ; Neubert, Patrick ; Ossner, Thomas ; Weigert, Anna ; Schatz, Valentin ; Toelge, Martina ; Schröder, Agnes ; Herrmann, Martin ; Schnare, Markus ; Dorhoi, Anca
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 01 Oct 2021 18:05


Infection and inflammation can augment local Na+ abundance. These increases in local Na+ levels boost proinflammatory and antimicrobial macrophage activity and can favor polarization of T cells towards a proinflammatory Th17 phenotype. Although neutrophils play an important role in fighting intruding invaders, the impact of increased Na+ on the antimicrobial activity of neutrophils remains ...


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