High Na+ Environments Impair Phagocyte Oxidase-Dependent Antibacterial Activity of Neutrophils

URN to cite this document:: urn:nbn:de:bvb:355-epub-460894
DOI to cite this document:: 10.5283/epub.46089

Jantsch, Jonathan ; Krampert, Luka

; Bauer, Katharina ; Ebner, Stefan ; Neubert, Patrick ; Ossner, Thomas ; Weigert, Anna ; Schatz, Valentin ; Toelge, Martina ; Schröder, Agnes

; Herrmann, Martin ; Schnare, Markus ; Dorhoi, Anca

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Date of publication of this fulltext: 01 Oct 2021 18:05

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Abstract

Infection and inflammation can augment local Na+ abundance. These increases in local Na+ levels boost proinflammatory and antimicrobial macrophage activity and can favor polarization of T cells towards a proinflammatory Th17 phenotype. Although neutrophils play an important role in fighting intruding invaders, the impact of increased Na+ on the antimicrobial activity of neutrophils remains ...