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Conserved strategies of RNA polymerase I hibernation and activation

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Heiss, Florian B. ; Daiß, Julia L. ; Becker, Philipp ; Engel, Christoph
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Jul 2021 16:16


RNA polymerase (Pol) I transcribes the ribosomal RNA precursor in all eukaryotes. The mechanisms 'activation by cleft contraction' and 'hibernation by dimerization' are unique to the regulation of this enzyme, but structure-function analysis is limited to baker's yeast. To understand whether regulation by such strategies is specific to this model organism or conserved among species, we solve ...


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