Conserved strategies of RNA polymerase I hibernation and activation

URN to cite this document:: urn:nbn:de:bvb:355-epub-463754
DOI to cite this document:: 10.5283/epub.46375

Heiss, Florian B. ; Daiß, Julia L. ; Becker, Philipp ; Engel, Christoph

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Date of publication of this fulltext: 15 Jul 2021 16:16

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Abstract

RNA polymerase (Pol) I transcribes the ribosomal RNA precursor in all eukaryotes. The mechanisms 'activation by cleft contraction' and 'hibernation by dimerization' are unique to the regulation of this enzyme, but structure-function analysis is limited to baker's yeast. To understand whether regulation by such strategies is specific to this model organism or conserved among species, we solve ...