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Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies

Sekula, Peggy ; Li, Yong ; Stanescu, Horia C. ; Wuttke, Matthias ; Ekici, Arif B. ; Bockenhauer, Detlef ; Walz, Gerd ; Powis, Stephen H. ; Kielstein, Jan T. ; Brenchley, Paul ; Eckardt, Kai-Uwe ; Kronenberg, Florian ; Kleta, Robert ; Köttgen, Anna ; Oefner, Peter J. ; Gronwald, Wolfram ; Zacharias, Helena


Background: Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Previous genome-wide association studies (GWAS) of 300 000 genotyped variants identified MN-associated loci at HLA-DQA1 and PLA2R1. Methods: We used a combined approach of genotype imputation, GWAS, human leucocyte antigen (HLA) imputation and extension to other aetiologies of chronic kidney disease ...


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