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Intracameral Delivery of Layer‐by‐Layer Coated siRNA Nanoparticles for Glaucoma Therapy

Dillinger, Andrea E. ; Guter, Michaela ; Froemel, Franziska ; Weber, Gregor R. ; Perkumas, Kristin ; Stamer, W. Daniel ; Ohlmann, Andreas ; Fuchshofer, Rudolf ; Breunig, Miriam


Glaucoma is the second leading cause of blindness worldwide, often associated with elevated intraocular pressure. Connective tissue growth factor (CTGF) is a mediator of pathological effects in the trabecular meshwork (TM) and Schlemm's canal (SC). A novel, causative therapeutic concept which involves the intracameral delivery of small interfering RNA against CTGF is proposed. Layer-by-layer ...


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