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Excessive release of endogenous neuropeptide Y into cerebrospinal fluid after treatment of spontaneous subarachnoid haemorrhage and its possible impact on self-reported neuropsychological performance – results of a prospective clinical pilot study on good-grade patients

Bründl, Elisabeth ; Proescholdt, Martin ; Schödel, Petra ; Bele, Sylvia ; Höhne, Julius ; Zeman, Florian ; Stoerr, Eva-Maria ; Brawanski, Alexander ; Schebesch, Karl-Michael


Objectives: Neuropsychological dysfunction after treatment of spontaneous subarachnoid haemorrhage (sSAH) is common but underreported. The vasoconstrictor neuropeptide Y (NPY) is excessively released after sSAH and in psychiatric disorders. We prospectively analysed the treatment-specific differences in the secretion of endogenous cerebrospinal fluid (CSF) NPY during the acute stage after sSAH ...


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