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Relative Impact of HLA Matching and Non-HLA Donor Characteristics on Outcomes of Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome

Ayuk, Francis ; Beelen, Dietrich W. ; Bornhäuser, Martin ; Stelljes, Matthias ; Zabelina, Tatjana ; Finke, Jürgen ; Kobbe, Guido ; Wolff, Daniel ; Wagner, Eva-Maria ; Christopeit, Maximilian ; Schmid, Christoph ; Ottinger, Hellmut ; Groth, Christoph ; Faul, Christoph ; Bertz, Hartmut ; Rachlis, Elena ; Wolschke, Christine ; Schetelig, Johannes ; Horn, Peter A. ; Mytilineos, Joannis ; Guellstorf, Martina ; Kelsch, Reinhard ; Fleischhauer, Katharina ; Kröger, Nicolaus ; Bethge, Wolfgang



Abstract

Increasing donor-recipient HLA disparity is associated with negative outcomes of allogeneic hematopoietic stem cell transplantation (HSCT), but its comparative relevance amid non-HLA donor characteristics is not well established. We addressed this question in 3215 HSCTs performed between 2005 and 2013 in Germany for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Donors were ...

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