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Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria

Schenk, Laura K. ; Buchholz, Bjoern ; Henke, Sebastian F. ; Michgehl, Ulf ; Daniel, Christoph ; Amann, Kerstin ; Kunzelmann, Karl ; Pavenstädt, Hermann


TMEM16A is a transmembrane protein from a conserved family of calcium-activated proteins that is highly expressed in the kidney. TMEM16A confers calcium-activated chloride channel activity, which is of importance for various cellular functions in secretory epithelia and involved in secretion-dependent renal cyst growth. However, its specific function in renal physiology has remained elusive so ...


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