Renner, Kerstin ; Metz, Sophia ; Metzger, Anne-Mieke ; Neumayer, Sophia ; Schmidbauer, Kathrin ; Talke, Yvonne ; Buchtler, Simone ; Halbritter, Dagmar ; Mack, Matthias
Alternative Links zum Volltext:DOIVerlag
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Cellular Immunology |
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| Verlag: | ACADEMIC PRESS INC ELSEVIER SCIENCE |
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| Ort der Veröffentlichung: | SAN DIEGO |
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| Band: | 334 |
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| Seitenbereich: | S. 49-60 |
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| Datum: | 2018 |
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| Institutionen: | Medizin > Abteilung für Nephrologie |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1016/j.cellimm.2018.09.005 | DOI |
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| Stichwörter / Keywords: | COLONY-STIMULATING FACTOR; HUMAN RECOMBINANT IL-3; DENDRITIC CELLS; HUMAN BASOPHILS; MEDIATOR RELEASE; LUPUS NEPHRITIS; HUMAN MONOCYTES; INTERLEUKIN-3; RESPONSES; DIFFERENTIATION; |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 46533 |
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Web of Science
Zusammenfassung
A large number of animal models revealed that IL-3 plays an important role for the development of T and B cell-mediated autoimmune diseases. However, little is known about the expression and regulation of IL-3 receptors in human T and B cells and how IL-3 modulates the activation and survival of these cells. We show that the IL-3 receptor CD123 is substantially upregulated on proliferating CD4(+) ...
Zusammenfassung
A large number of animal models revealed that IL-3 plays an important role for the development of T and B cell-mediated autoimmune diseases. However, little is known about the expression and regulation of IL-3 receptors in human T and B cells and how IL-3 modulates the activation and survival of these cells. We show that the IL-3 receptor CD123 is substantially upregulated on proliferating CD4(+) and CD8(+) T as well as B cells. Upregulation of CD123 differs between various activators and can be further modulated by cytokines. Exposure of human T and B cells to IL-3 enhances proliferation and survival. IL-3 also induces a shift towards secretion of proinflammatory cytokines in T and B cells and reduces the expression of IL-10 in B cells. Thus IL-3 may have proinflammatory and immunostimulatory properties also in human autoimmune diseases.
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