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Moving forward toward standardizing analysis of quality of life data in randomized cancer clinical trials

Bottomley, Andrew ; Pe, Madeline ; Sloan, Jeff ; Basch, Ethan ; Bonnetain, Franck ; Calvert, Melanie ; Campbell, Alicyn ; Cleeland, Charles ; Cocks, Kim ; Collette, Laurence ; Dueck, Amylou C. ; Devlin, Nancy ; Flechtner, Hans-Henning ; Gotay, Carolyn ; Greimel, Eva ; Griebsch, Ingolf ; Groenvold, Mogens ; Hamel, Jean-Francois ; King, Madeleine ; Kluetz, Paul G. ; Koller, Michael ; Malone, Daniel C. ; Martinelli, Francesca ; Mitchell, Sandra A. ; Moinpour, Carol M. ; Musoro, Jammbe Z. ; O’Connor, Daniel ; Oliver, Kathy ; Piault-Louis, Elisabeth ; Piccart, Martine ; Pimentel, Francisco L. ; Quinten, Chantal ; Reijneveld, Jaap C. ; Schürmann, Christoph ; Smith, Ashley Wilder ; Soltys, Katherine M. ; Sridhara, Rajeshwari ; Taphoorn, Martin J. B. ; Velikova, Galina ; Coens, Corneel



Abstract

Background There is currently a lack of consensus on how health-related quality of life and other patient-reported outcome measures in cancer randomized clinical trials are analyzed and interpreted. This makes it difficult to compare results across randomized controlled trials (RCTs) synthesize scientific research, and use that evidence to inform product labeling, clinical guidelines, and health ...

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