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Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells

Bodogai, Monica ; O’Connell, Jennifer ; Kim, Ki ; Kim, Yoo ; Moritoh, Kanako ; Chen, Chen ; Gusev, Fedor ; Vaughan, Kelli ; Shulzhenko, Natalia ; Mattison, Julie A. ; Lee-Chang, Catalina ; Chen, Weixuan ; Carlson, Olga ; Becker, Kevin G. ; Gurung, Manoj ; Morgun, Andrey ; White, James ; Meade, Theresa ; Perdue, Kathy ; Mack, Matthias ; Ferrucci, Luigi ; Trinchieri, Giorgio ; de Cabo, Rafael ; Rogaev, Evgeny ; Egan, Josephine ; Wu, Jiejun ; Biragyn, Arya


Aging in humans is associated with increased hyperglycemia and insulin resistance (collectively termed IR) and dysregulation of the immune system. However, the causative factors underlying their association remain unknown. Here, using "healthy" aged mice and macaques, we found that IR was induced by activated innate 4-1BBL + B1a cells. These cells (also known as 4BL cells) accumulated in aging in ...


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