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CureCuma–cationic curcuminoids with improved properties and enhanced antimicrobial photodynamic activity

Spaeth, Andreas ; Graeler, Andre ; Maisch, Tim ; Plaetzer, Kristjan



Zusammenfassung

The naturally occurring photosensitizer curcumin has excellent biocompatibility, but its antimicrobial photodynamic efficacy is limited by (i) weak adherence to Gram(-) bacteria cell walls, (ii) low (photo-) stability and (iii) limited solubility in water. In this study novel curcuminoids bearing cationic substituents were prepared by different synthetic routes. The derivatives exhibit excellent ...

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