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Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS

Hacker, Carolin ; Cai, Xiaofeng ; Kegler, Carsten ; Zhao, Lei ; Weickhmann, A. Katharina ; Wurm, Jan Philip ; Bode, Helge B. ; Wöhnert, Jens



Abstract

Several peptides in clinical use are derived from non-ribosomal peptide synthetases (NRPS). In these systems multiple NRPS subunits interact with each other in a specific linear order mediated by specific docking domains (DDs), whose structures are not known yet, to synthesize well-defined peptide products. In contrast to classical NRPSs, single-module NRPS subunits responsible for the generation ...

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