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Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survival

Beier, Christoph Patrick ; Rasmussen, Tine ; Dahlrot, Rikke Hedegaard ; Tenstad, Helene Broch ; Aarø, Julie Slinning ; Sørensen, Mai Froberg ; Heimisdóttir, Sólborg Berglind ; Sørensen, Mia Dahl ; Svenningsen, Per ; Riemenschneider, Markus J. ; Beier, Dagmar ; Kristensen, Bjarne Winther


The mechanisms of glioma-associated seizures (GAS) have yet to be fully elucidated. Proneural subtype, isocitrate dehydrogenase 1 (IDH1) mutations, and epileptic seizures are closely associated suggesting that aberrant neuronal differentiation contributes to glioma-associated seizures. In a population-based cohort (n = 236), lack of stem cell marker expression (nestin, musashi) was significantly ...


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